产品
  • 产品
搜索

再生医学培养基供应商

弗元生物-再生医学培养基 >> 资 料 >>文章发表 >> 2020 PM2.5 promote the expression of TSLP
详细内容

2020 PM2.5 promote the expression of TSLP

 2020 Mar-Apr;65(2):92-96. doi: 10.4103/ijd.IJD_520_18.

Fine Particulate Matter (PM2.5) is a Risk Factor for Dermatitis by Promoting the Expression of Thymic Stromal Lymphopoietin (TSLP) in Keratinocytes.

Li F1Dong Y2Ni C1Kan H3Yan S1.

Author information

1
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
2
Fuyuan (Shanghai) Biotechnology Co. LTD, Shanghai, China.
3
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.

Abstract

AIM:

Common indoor pollutants, as fine particulate matter (PM2.5), can damage people's health and cause skin allergies. However, it remains unknown which common pollutants can lead to allergy, such as, in children atopic dermatitis, and what is the key molecule. This study aimed to investigate the thymic stromal lymphopoietin (TSLP) produced from keratinocytes after environmental pollutant stimulation.

METHODS:

PAM212 cells were treated by several pollutants, including PM2.5, formaldehyde, m-xylene, and 1,2,4-trimethylbenzene, and tried to analyze their relationships. The mRNA expression level of TSLP was determined by qPCR. The protein level of TSLP was detected by ELISA analysis.

RESULTS:

The mRNA expression of TSLP was significantly up-regulated when PAM212 cells were stimulated by PM2.5 at 25 μg/ml for 12 h. Meanwhile, the protein level of TSLP in culture supernatant was increased. However, TSLP protein production was not detected in culture supernatant treated with formaldehyde, m-xylene, and 1, 2, 4-trimethylbenzene.

CONCLUSION:

PM2.5 promotes the expression of TSLP and may aggravate allergic response using this pathway.

KEYWORDS:

Atopic dermatitis; PM2.5; keratinocyte cell; thymic stromal lymphopoietin

PMID:
 
32180593
 
PMCID:
 
PMC7059460
 
DOI:
 
10.4103/ijd.IJD_520_18

2020-PM2.5-is-a-risk-factor-for-dermatitis.jpg

2020 PM2.5-is-a-risk-factor-for-Dermatitis.pdf





  • 电话直呼

    • 021-80370389
    • 17621586186
    • 13671816350
    • 13041694656
    • 产品订购1 :
    • 产品订购2 :
    • 技术服务1 :
    • 技术服务2 :
    • 技术服务3 :
  • 微信联系

技术支持: zqjq | 管理登录
0
×

购物车

商品名称 数量 产品单价 折扣 总计
金额总计:¥23立即结算
seo seo