Zhao ZH, Ma XL, Ma JX, Kang JY, Zhang Y, Guo Y. Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration. Mater Today Bio. 2022 Jan 23;13:100206. doi: 10.1016/j.mtbio.2022.100206. PMID: 35128373; PMCID: PMC8808263.

Zhi-hu Zhao, Xin-long Ma, Jian-xiong Ma, Jia-yu Kang, Yang Zhang, Yue Guo,

Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration,

Materials Today Bio,

2022,

100206,

ISSN 2590-0064,

https://doi.org/10.1016/j.mtbio.2022.100206.

(https://www.sciencedirect.com/science/article/pii/S2590006422000047)

Abstract: Bone defects are a common challenge in the clinical setting. Bone tissue engineering (BTE) is an effective treatment for the clinical problem of large bone defects. In this study, we fabricated silk fibroin (SF)/hydroxyapatite (HAp) scaffolds inlaid with naringin poly lactic-co-glycolic acid (PLGA) microspheres, investigating the feasibility of their application in BTE. Naringin PLGA microspheres were manufactured and adhered to the SF/HAp scaffold. Bone mesenchymal stem cells (BMSCs) were inoculated onto the SF/HAp scaffold containing naringin PLGA microsphere to examine the biocompatibility of the SF/HAp scaffolds. A rabbit femoral distal bone defect model was used to evaluate the in vivo function of the SF/HAp scaffolds containing naringin-loaded PLGA microspheres. The current study demonstrated that SF/HAp scaffolds containing naringin-loaded PLGA microspheres show promise as osteo-modulatory biomaterials for bone regeneration.

Keywords: Naringin; Silk; Hydroxyapatite; Bone defect; PLGA; Microsphere